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doi: 10.1016/j.jmsacl.2021.12.005 41 PonzoniASpecaSHartleMGerstenbergATomezykASenechalVet al

Urinary excretion of 5-oxoproline (pyroglutamic aciduria) as an index of glycine insufficiency in normal man

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However, their clinical application faced challenges related to variable bioavailability, individual pharmacokinetics, optimal dosing, and limited clinical evidence