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This indicates that nNOS activation is a prerequisite for PER2 downregulation and the subsequent neuroprotection, a mechanism exclusively triggered during the inactive phase ( In summary, circadian rhythm critically affects the efficacy of RIPostC and may explain inconsistent clinical outcomes

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As ATP6AP1 KO cells display a higher glucose uptake and rate of glycolysis, cytosolic pH alkalinization might promote this phenomenon as glycolytic enzymes generally perform most efficiently in a slightly alkaline environment (around pH 7.58.0) 68,69

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Very high body temperatures can cause direct cellular, neurological, and multiorgan injury, although this is more characteristic of hyperthermia or hyperpyrexia than ordinary regulated infectious fever