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This includes the response generated by the skin's immune system when exposed to biological insults/trauma or the synthesis of factors like parathyroid hormone-related protein (PTHrP), proopiomelanocortin-derived (POMC) -endorphin peptides, corticotropin-releasing hormone (CRH) and urocortin peptides, catecholamines, and acetylcholine that respond to specific stimuli

They showed that as the concentration of LPS increased, the activity of Caspase3/7 rose, the expression of the pro-oncogene Bax increased and the tumor suppressor gene Bcl-2 decreased (Liu et al., 2020) ( Figure 1 )

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