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In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice, a well-established animal model of PD, AD AD is the most common type of irreversible dementia and a neurodegenerative disease that often occurs in the elderly

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AGS cells were cultured in DMEM/F12 with 10% FBS, hUC-MSCs were cultured in Human umbilical cord blood mesenchymal stem cell complete medium (Pricella, China), supplemented with 1% penicillin/streptomycin (Meilunbio, China)

Cysteine-dependent aspartate-specific proteases (caspases) are efficient enzymes with defined substrate specificity