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The solid oral pharmaceutical composition according to any one of items 1 , 2 and 8 to 10, wherein the copolymer (A) in the first coating comprises not more than 3 mol-% methyl acrylate repeating units, preferably wherein the copolymer (A) comprises not more than 1 mol-%, more preferably not more than 0.5 mol-%, even more preferably not more than 0.1 mol-%, yet even more preferably not more than 0.01 mol-%, still more preferably 0 mol-% methyl acrylate repeating units

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Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function