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In the five studies (schizophrenia = 94, HV = 82) of mRNA expression there was a significant reduction (effect size = 0.64) in schizophrenia

But tag selection is far from one-size-fits-all a poor choice can reduce expression levels, lower purification efficiency, or cause abnormal protein structure and loss of function

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Iron overload enhances glycolysissupporting the M1 phenotype-and increases ROS production and p53 acetylation, further driving M1 polarization