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Rhein can reduce the expression of fat mass and obesity-associated protein [106], and also mitigate oxidative stress and lipid metabolism in HFD rats [107], which may be associated with downregulation of TLR4, MYD88 and Cyr61 [108]

Further study is needed to determine the mechanisms by which phosphorylation results in exclusion of NS3 from the cytoplasm and loss of its VSR activity