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The exosome biogenesis relies on neutral sphingomyelinase 2, which produces ceramide, and blocking ceramide reduces the release of miRNA-loaded vesicles (82)

Intervention of lactylation-related enzymes The majority of lactylation is mediated by enzymes, making the targeted intervention of these key regulatory enzymes, particularly the writers, a crucial focus for research into targeted therapy strategies for lactylation

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Behavioral effects of cocaine mediated by nitric oxide-GAPDH transcriptional signaling

Bouchard C, Dubuc G, Davignon J, Bernier L, Cohn JS