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Importantly, the same authors also reported that AML cells were unable to synthetize cysteine from methionine providing an opportunity to exploit this vulnerability for AML treatment

Intramuscular injections (1,000 mcg cyanocobalamin) given weekly for 4 weeks, then monthly, remain the standard for pernicious anemia or severe malabsorption [3]

Thus, despite preventing fork breakage during S phase, fork reversal can be a source of chromosomal instability if the reversed forks are not restarted before the onset of anaphase (Fig

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The SH-group on cysteine is the link through which diverse defense pathways are combined in GSH that will be further discussed in this review