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diffuse axonal injury (more than three lesions) depending on the severity of the impact ( Cognitive impairmentsparticularly persistent memory deficitsare among the most frequently reported long-term consequences of TBI ( The disruptions to the dopamine and noradrenaline networks due to TBI are fairly common ( Our group has recently published findings on the use of guanfacine, an alpha-2A noradrenergic agonist, for treating patients with mild TBI who exhibit deficits in working memory and executive functioning (32), guanfacine treatment was shown to enhance working memory in patients with mild TBI, as demonstrated by increased right PFC activation on fMRI

The major source of ROS production in hepatocytes is NADH and NADPH oxidases localized in mitochondria (Figure 1)

We did not feel that charting the above side effects was necessary, as this was a safety study

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