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Description

Low-molecular-weight thiols in thioldisulfide exchange

However, with aging, the efficacy of key UPRER regulators such as PERK, IRE1, ATF6, among others, diminishes, leading to challenges in ER stress mitigation and an increased susceptibility to pathological UPRER activation [326,327,328]

54 A negative APAP reading should not be interpreted as APAP-related hepatic injury having not taken place, as levels may be undetectable while liver damage has already occurred