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Cell Commun Signal 23 , 4 (2025)

Mechanism of Action: Why It Makes Sense for Athletes Sermorelin binds to GHRH receptors in the anterior pituitary, increasing pulsatile GH release and downstream insulin-like growth factor-1 (IGF-1) production. Growth hormone and IGF-1 influence several systems relevant to performance: Protein synthesis and muscle repair Collagen formation and tendon remodeling Lipolysis and metabolic efficiency Sleep architecture, particularly slow-wave sleep Because GH secretion is naturally highest during deep sleep, sermorelin is typically administered at night to align with this physiology

Azzam 2 , Mostafa Moawad 3 , Ibrahim Serag 1 , Abdallah Abbas 4 , Ahmed E

Enhances Skin Elasticity: Beyond muscle relaxation, Leuphasyl supports collagen synthesis and skin elasticity, creating a firming effect that complements its wrinkle-smoothing properties

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