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A small, randomized, controlled clinical trial that was published in 2020 found that there was a statistically significant reduction in intense pain, sharp pain, and cold and itchy sensations in the CBD group when compared to the placebo group. However, a study published in 2023 found no significant difference in neuropathy pain relief effects between cannabis-derived medicines and a placebo

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(2014, Nature Medicine) established NNMT as a major regulator of metabolic rate in white adipose tissue, showing that NNMT knockdown in mice produced a lean phenotype with elevated energy expenditure providing the foundational rationale for NNMT inhibition as a metabolic research target