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FOXO3a itself induces a set of atrophy-related genes, specifically the muscle-specific ubiquitin ligases, MAFbx and MuRF-1, which promote the breakdown of the myofibrillar apparatus [17]

These residues are located at the end of the groove and electrostatically interact with the coactivator backbone, thus forming a charge clamp between the amide nitrogen of F+1 and E897 and the carbonyl group of F+5 and K720 (Figure 3D, middle panel)

2007;67(10):13481361 DOI: 10.1002/dneu.20506 35

Multivitamins are intended to be a complementary measure and should not be considered a substitute for a diverse and nutritious food intake

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