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Instead, it acts as an intracellular signaling peptide, engaging the AMPK pathway and influencing nuclear gene expression via a mitochondrial-nuclear retrograde signaling mechanism

Lab tests show pp 332 activation leads to suppression of lipogenic gene expression and activation of genes involved in mitochondrial biogenesis

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Clinical trials measuring body composition found that fat mass reduction occurred without corresponding increases in lean tissue mass, confirming the absence of anabolic muscle-building effects