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Therefore, if apixaban is prematurely discontinued for another reason other than a pathological bleed, consider starting another anticoagulant

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We are codifying that for single source drugs that are not biosimilars with all negative or zero ASP data for a given quarter, the payment limit will be, until at least one NDC for the drug has positive manufacturer ASP data for a quarter, the lesser of 106 percent of the volume-weighted average of the most recently available positive manufacturer ASP data for at least one NDC from a previous quarter and 106 percent of the WAC, and we will use 106 percent of the lowest WAC per billing unit if there is more than one WAC per billing unit

Br J Pharmacol 164(2b):644654 Lin Y, Shi R, Wang X, Shen HM (2008) Luteolin, a flavonoid with potential for cancer prevention and therapy