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The gene product (CFTR) is a large (1480 amino acids, 175000 Daltons), ligand gated ion channel belonging to the ABC transporter family

The detailed description of the protocol used as well as demographic and clinical characteristics of participants have been described in a separate study previously published ( To further assess the effect of NAC treatment in modulating host immune response, we measured the concentration of several cytokines, chemokines, growth factors and lipid mediators in plasma isolated from patients receiving or not NAC at the study baseline and day 60 of treatment (see Methods for details in the choice of the parameters)

revealed that BMSC-Exos suppress hippocampal ferroptosis and upregulate key antioxidant proteins, including SIRT1, Nrf2, and HO-1, which enhance cellular resistance to oxidative damage