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A new perspective on vitamin B12 deficiency in rheumatology: a case-based review

Vitamin B Complex refers to a group of eight essential B vitamins that play vital roles in cellular metabolism, energy production, brain function, and the synthesis of red blood cells

For individuals requiring supplementation due to confirmed deficiency or malabsorption, therapeutic doses vary considerably depending on the underlying cause: Dietary deficiency : 50150 micrograms daily orally, or cyanocobalamin tablets as prescribed Pernicious anaemia : Initially hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks, then maintenance injections every two to three months [3] Neurological involvement : More intensive regimens may be required, with hydroxocobalamin injections on alternate days until symptom improvement [3] NICE guidance emphasises that supplementation should be evidence-based rather than speculative

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Patients experiencing this may prefer evening administration to avoid daytime lethargy affecting work or daily activities