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In preclinical research, it has been observed to influence local anabolic signaling following mechanical stress

[] A phase 3 double-blind, placebo and randomized controlled clinical trial, which studied the long-term effect of OCA in PBC patients, who did not tolerate or respond to UDCA therapy, revealed that OCA improved liver fibrosis and biliary injury in PBC patients after three years of treatment

Ferroptosis, driven by iron-dependent lethal lipid peroxidation, can be inhibited through direct blockade of lipid peroxidation or iron depletion via pharmacological or genetic approaches [21]

FOXO4-DRI, also designated Proxofim, has an approximate molecular weight of 5400 g/mol

*Correspondence: Haifeng Wang [email protected] This article was submitted to Nutrition and Metabolism, a section of the journal Frontiers in Nutrition Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers