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In a specific cytokine environment, CD4 + T cells stimulated by antigens activate and differentiate into different subsets of helper T (Th) cells, including Th1, Th2, Th9, Th17, Th22, T regulatory (Treg), and T follicular helper (Tfh) cells

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The PRNP promoter contains metal-responsive elements that are targeted by the metal-sensitive transcription factor MTF1, which transactivates PRNP in response to Cu 23

Biol Trace Elem Res 188:1125

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