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van den Berg, D

It can modify many transcription factors in macrophages, including hypoxia-inducible factor (HIF-1 ), nuclear factor-k-B binding (NF-kB), and interferon regulatory factors (IRFs) (99)

Copper is essential for numerous enzymatic processes including collagen cross-linking, elastin formation, antioxidant defense (superoxide dismutase), and angiogenesis