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The Tomas in vivo characterization in protein-restricted rats reported that IGF-I analogs that bind IGFBPs poorly including LR3-IGF-1 produce greater anabolic effects than equimolar native IGF-1 when administered by either continuous infusion or daily injection, with the differential most pronounced under injection conditions [2]

10.1186/s12979-023-00383-3 44

They do not suit human use, and trained staff follow strict laboratory safety rules at all times

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Cells were mounted with PBS/glycerol (1:9, v/v) under glass slides, and the results were visualized with fluorescence microscope Nikon DS-Ri1 (Nikon)