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Nrf2 interference following, GB therapy dramatically increased Nrf2 expression, suggesting that GB can be used to treat ferroptosis induced by lipid accumulation and oxidative stress in response to NAFLD via the Nrf2 signalling pathway

Early-phase clinical trials should assess safety and tolerability in both healthy volunteers and patient populations, supported by systematic monitoring of adverse events

J Neurochem 78(2):249253 Hsu C-C, Cheng C-H, Hsu C-L, Lee W-J, Huang S-C, Huang Y-C (2015) Role of vitamin B6 status on antioxidant defenses, glutathione, and related enzyme activities in mice with homocysteine-induced oxidative stress

Mitochondrial-Specific Protection: For conditions involving mitochondrial dysfunction, such as chronic fatigue syndrome, certain neurodegenerative disorders, or metabolic diseases, hydrogen's ability to penetrate mitochondria may offer targeted benefits that mineral cofactors alone cannot provide

Because this review is narrative in nature, formal systematic review criteria were not used to select studies, and no quantitative synthesis was performed