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Over the past decade, increasing evidence has revealed that disturbances in riboflavin metabolism, transport, or utilization contribute to a spectrum of neurological disorders

In general, NSAIDs display small volumes of distribution, high plasma-protein binding, limited first-pass hepatic metabolism and good oral absorption

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DNA methylation is one of the key epigenetic mechanisms for regulation of gene expression which is currently a subject of intensive research and it was reported that maternal deficiency of folate and B 12 could result in aberrant gene expression with consequential health outcomes (Reference Irwin, Pentieva and Cassidy126,Reference Monasso, Hoang and Mancano127)