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These increases in heart rate are more pronounced in the longer-acting GLP-1 agonists such as semaglutide and tirzepatide. Aside from heart conditions, you should also avoid semaglutide if you have any of the following conditions or situations: Type 1 diabetes mellitus A history of medullary thyroid carcinoma (MTC) Chronic stomach problems Eye disease or vision problems Medical history of pancreatitis Hypersensitivity to the drugs or its active ingredients Severe gastrointestinal diseases Kidney disease Are pregnant or breastfeeding If you have a pre-existing heart condition, please notify your healthcare provider so that they can decide whether semaglutide is a safe medication for you