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10.3389/fpsyt.2013.00039 93 OkitaK.MoralesA

86 Notch signaling pathway Notch signaling, intimately involved in embryonic development and maintenance of multicellular organisms in adults, is activated by ligand-receptor interaction between adjacent cells, which leads to successive proteolytic cleavages and releases the notch intracellular domain (NICD)

This decline is thought to contribute to many age-related changes in skin, hair, and overall tissue health

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Emerging therapies, including TYK2 and RORt inhibitors, offer new hope with potentially improved safety margins, yet their long-term hepatic effects remain to be fully elucidated