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Molecular mechanisms underlying vascular remodeling in hypertension

Rhein, one of the anthraquinone ingredients in the root of rhubarb, inhibits the phosphorylation of PI3K/AKT/FOXO3a, resulting in sustained high levels of Bim expression, which ultimately induces caspase cleavage and apoptosis [163]

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A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer

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