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When joint discomfort occurs after starting B12, it is typically coincidental or related to other factors such as excipients in formulations, injection-site effects, pre-existing musculoskeletal conditions, or rare hypersensitivity reactions rather than a direct effect of the vitamin itself

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Nevertheless, there are numerous potential STAT-binding elements, which are likely to regulate STAT3 responsiveness ( NNMT expression and promoter activity ( NNMT gene are also associated with many diseases