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Targeted Natural Supplements Based on current evidence, the following natural supplements are most supported for detoxification: Milk thistle (silymarin) : for liver protection and support, particularly valuable when pets are on medications or have had toxic exposures Probiotics (such as MicroMed): for gut microbiome health, immune support, and emerging evidence of direct toxin elimination Omega-3 fatty acids : for anti-inflammatory effects and skin barrier integrity Curcumin/turmeric : for antioxidant support and liver health (dogs primarily