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Reduction of urinary sulfate levels was associated with improvement in clinical symptoms as reported by caregivers

10.1007/s00296-016-3551-y 287

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(35837678) For patients who refuse buprenorphine therapy , inpatient methadone may be utilized even if there isnt a pre-defined discharge strategy

Due to deficiencies in mtDNA repair mechanisms, lack of histone protection, and the proximity of mtDNA to the IMM where ROS are generated, mtDNA is highly susceptible to oxidative damage [81]