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doi: 10.1016/j.livprodsci.2005.10.009 49 GrauletB.RichardC.RobertJ

This is a very interesting question that comes up quite often

, Board-Certified Emergency Medicine Physician and Co-Founder, Amanecia Health Last reviewed June 18, 2026 by Lauren Leavitt, M.D., Board-Certified Emergency Medicine Physician, Amanecia Health

Because retatrutide includes GLP-1 agonism (which semaglutide was providing) plus GIP and glucagon agonism, the transition should not result in loss of appetite suppression during the switch