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Int J Mol Sci 24(9):7791

Further, the pro-inflammatory gene expression profiles of WT lesions from HFD-fed and CD-fed recipients differed only modestly (mostly non-significant), findings consistent with the limited and selective differences in the two groups systemic, local (peritoneal), and genomic (DNA damage) redox status

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The resulting DHA-derived peroxidation adducts, such as 4-hydroxy-7-oxohept-5-enoic acid-lactone-glutathione (HOHA-lactone-GSH), 4,7-dihydroxyhept-5-enoic acid-lactone-glutathione (DHHA-lactone-GSH) and carboxyethylpyrrole (CEP), were quantified using LCMS/MS or immunohistochemistry