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Correspondingly, amongst studies on neuropathic pain, Mario Delgados team proposed in 2014 that CST, a natural analgesic component of the peripheral injury receptor system, produced by peptidergic injury receptor neurons in the DRG in response to inflammation and noxious stimuli (123), plays an essential pain suppressing role in persistent inflammatory pain

Furthermore, increased secretion of TNF- and IL-1 in GC tissues promotes TGF-1/Smad signaling by regulating rhomboid 5 homolog 2 (RHBDF2) [68] (circle marked 5 in Fig