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Despite its proposed role in inhibiting protein aggregation, including amyloid-beta and tau, metformin has been shown to upregulate BACE1 (-site amyloid precursor protein-cleaving enzyme 1), the key enzyme that produces A from its precursor protein [175]

Blood-brain barrier perturbations by uremic toxins: key contributors in chronic kidney disease-induced neurological disorders

doi: 10.1155/2022/7282453 176

Interaction of nanoparticles and cell-penetrating peptides with skin for transdermal drug delivery

SAG S-acetyl glutathione Glutathione is a compound which, in its reduced form, constitutes an excellent antioxidant and therefore a defence against the damage caused by free radicals to higher organisms