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There are some mechanisms involved in GSH diminution: increased oxidation by intracellular oxidizing agents, increased conjugation to molecules, and increased exit across the cell membrane [137]

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However, a simple increase in payload conjugation at high DAR can lead to conjugate hydrophobicity, leading to faster clearance by the mononuclear phagocyte system and accelerated plasma elimination, rather than renal clearance which is predominant for small molecules [52]

DDX3X is a pivotal regulator of cysteine-glutathione metabolism and ferroptosis in lung cancer cells To study the role of DDX3X in lung cancer progression, we undertook a label-free proteomic analysis using DDX3X knockdown (shDDX3X) A549 cells

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