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GO enrichment analysis of the 248 overlapping DEGs revealed significant enrichment in terms including inflammatory response, steroid metabolic process, cholesterol metabolic process, retinoid metabolic process, metal ion transmembrane transporter activity, heme binding, oxidoreductase activity, and iron ion binding (Fig

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Current guidelines recommend the use of sodium bicarbonate in patients with CKD and metabolic acidosis, with a target serum bicarbonate level 22 mEq/L