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This differentiation potential enables the generation of disease-specific cells, such as cardiomyocytes for heart diseases or neurons for neurodegenerative disorders [568, 575, 584]

His-tagged E2E1-foldon trimers were purified from 293 F supernatant using NiNTA agarose beads (Qiagen) and polished using a Superdex 200 Increase column in PBS