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Thus, PLA2 activity represents a critical metabolic junction that coordinates inflammation, stromal remodeling, and cell death pathways, generating both the signaling lipids that modulate the TME and the oxidizable lipid substrates required for ferroptotic cell death

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In addition, simvastatin increased the expression of co-stimulatory molecules, production of IL-1 and IL-12p70, apoptosis, and autophagy in Mtb-infected monocytes (143)