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Harris BE, Song R, Soong SJ, Diasio RB (1990) Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion

For example, in HCC patients, gut microbe-associated feature scores showed cancer-type-specific genomic alterations and immune microenvironment feature associations, and can serve as potential clinical biomarkers for immunotherapy responsiveness and recurrence in multiple malignancies, providing a comprehensive framework for quantifying microbe-driven transcriptional activity and its clinical significance in cancer