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Patient selection criteria are not well-established, and determining which patients are most likely to benefit from these therapies requires clinical judgment based on limited evidence

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The Soviet Union had a problem: its soldiers, including submariners, missile operators, and fighter pilots, were aging too fast

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Troncone and Ferguson, 1988), particularly humanised models that are transgenic for several human genes relevant to the disease, such as NOD.DQ8/A 0 (Galipeau et al, 2011), hCD4.DR3-DQ2.MHCII / (de Kauwe et al, 2009), and DQ8-D d -IL-15tg (DePaolo et al, 2011) mice