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XRCC4 knockdown did not significantly alter the expression of these p53 target genes (Supplementary Fig

J Immunol 179(6):41804186 Liu MJ, Bao S, Glvez-Peralta M, Pyle CJ, Rudawsky AC, Pavlovicz RE, Killilea DW, Li C, Nebert DW, Wewers MD, Knoell DL (2013) ZIP8 regulates host defense through zinc-mediated inhibition of NF-B

In the HLA-matched setting, recurrent HLA loss and downregulation of MHC class II genes have also been identified as a mechanism of leukemic escape and relapse, likely due to loss of leukemia-associated antigens and/or mHAgs (204, 205)