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Glyoxalases (GLO), comprising of GLO-I, II and III, are involved in the detoxification of reactive -oxoaldehydes to D-lactate and oxalate ( Protein covalent modification by AGEs results in functional impairment and formation of toxic protein inclusions associated with various NGDs It has been understood that post-translational modification of proteins brings about alteration in the native state structural integrity leading to at least 2 consequences (Figure 1)

Olezarsen, acute pancreatitis, and familial chylomicronemia syndrome

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For instance, nitrogen dioxide and polychlorinated biphenyls are directly correlated with an elevated risk of ASD (Stein et al., 2023)