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The chloroacetamide moiety embedded in the chemical structure of RSL3 and ML162 contributes to their GPX4 inhibitory activity [217]

59 As shown in Table 2, Fibroblast growth factor 9, 60 Curcumin, 61 catalase, 61 Ellagic acid, 62 Allicin, 63 Sulforaphane, 63 Lycopene 63 and Cudratricusxanthone O 64 can activate NRF2 in chondrocytes, thereby activating antioxidant enzymes such as HO-1, SOD, and GPx, effectively reducing oxidative stress levels in OA chondrocytes

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