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10.1002/jcsm.13213 12 DongL.XieJ.WangY.JiangH.ChenK.LiD.et al (2022)

Chronic hypoxia promotes ceramide hydrolytic metabolism by activating the HIF-2/Acer2 signaling pathway, and thereby downregulates PP2A activity The above study found that hypoxia caused -syn hyperphosphorylation by inhibiting PP2A activity