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These high neurohormone levels were associated with pulmonary haemodynamic derangements, limitations in RV functional reserve, reduced cardiac output and more profoundly impaired exercise capacity in HFpEF ( Table 2 ).94 Recently, ADM has been identified as an important marker of volume expansion and prognostically relevant feature in HFpEF patients with an obese phenotype with important prognostic implications.95 Endothelin ET is the most potent vasoconstrictor peptide known in humans

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Lanzkron S, Carroll CP, Haywood C Jr (2013) Mortality rates and age at death from sickle cell disease: U.S., 19792005