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Furthermore, hypothalamic inflammation alters the pulsatile secretion pattern of gonadotropin-releasing hormone (GnRH), resulting in an increase in luteinizing hormone (LH)/follicle stimulating hormone (FSH) ratios and leading to irregular menstrual cycles and ovulatory disorders (90)

This finding is not surprising, given the striking association between BMI and HF risk in patients with T2D emerging from the Swedish National Diabetes Registry 88