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However, the current pyroptosis-induced drugs have some limitations, such as high toxicity, poor stability, and low intracellular accumulation

Kankala, R

Its usually instability in the sacrum where the muscle is attached

Med Clin North Am (2020) 104(2):21338

In contrast, a prospective, randomized clinical trial of 80 patients with advanced HCC treated with sorafenib plus metformin or sorafenib alone revealed that adding metformin to sorafenib did not improve treatment efficacy in patients with HCC [224]