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Mitophagy Mitophagy is an evolutionarily conserved mechanism that eliminates ROS-producing mitochondria via autophagy, which has a complex relationship with oxidative stress (Schofield and Schafer 2021)

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This is possibly due in part to the loss of the negative feedback circuit from mTORC1 to the PI3K/AKT/mTORC2 signaling axis, which mediates cell survival