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Some individuals experience stinging, pain, or tingling instead of itching. Other symptoms of vitamin B12 deficiency Other symptoms of the condition are listed by Bupa as: Feeling very tired Breathlessness even after a little exercise Heart palpitations Headaches A reduced appetite A sore mouth The health organisation adds: If you have vitamin B12-deficiency anaemia, you may also look pale or jaundiced (have a yellowy tinge to your skin and the whites of your eyes)

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Strikingly, substitution of proline at position 3 (P3A) abolished binding, yielding a KD = 56.7 (Fig

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