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In the 13 studies (Figure 2) that reported hospital mortality, a significant reduction in hospital mortality was seen when they were aggregated (RR 0.68, 95% CI 0.51, 0.90, P = 0.008, heterogeneity I 2 = 0%)

Figures 3 and 4 show the metabolite concentration levels for the two groups and hemispheres

Methods: High coverage whole exome sequencing and variant identification and annotation were performed by the Regeneron Genetics Center as published previously (N Engl J Med 2022